The results of a phase 3 clinical trial published in JAMA demonstrate that oral lefamulin, a novel antibiotic recently approved by the US Food and Drug Administration (FDA), is non-inferior to oral moxifloxacin for the treatment of community-acquired bacterial pneumonia (CABP).Lefamulin is a first-in-class, semi-synthetic pleuromutilin antibiotic designed to inhibit the synthesis of bacterial protein, which is required for bacterial growth. It’s indicated for treatment of CABP caused by the most common gram-positive and gram-negative bacteria associated with the disease, including Streptococcus pneumoniae, methicillin-susceptible Staphylococcus aureus, Mycoplasma pneumoniae, and Haemophilus influenzae.In the Lefamulin Evaluation Against Pneumonia (LEAP) 2 trial, a team led by researchers from drug sponsor Nabriva Therapeutics of Dublin randomized 738 patients with CABP 1:1 to receive either 5 days of oral lefamulin (370 patients) or 7 days of oral moxifloxacin (368 patients).The FDA primary end point was early clinical response at 96 hours after the first dose of either study drug in the intention-to-treat (ITT) population. The secondary end points were investigator assessment of clinical response at test of cure in the modified ITT population and in the clinically evaluable population. The non-inferiority margin was 10%.The early clinical response rates in the ITT population were 90.8% for the lefamulin group vs 90.8% for the moxifloxacin group (difference, 0.1 percentage points). Rates of investigator assessment of clinical response success were 87.5% with lefamulin and 89.1% with moxifloxacin in the modified ITT population (difference, –1.6 percentage points) and 89.7% and 93.6%, respectively, in the clinically evaluable population (difference, –3.9 percentage points) at test of cure.The overall incidence of treatment-emergent adverse events was 32.6% with lefamulin and 25.0% with moxifloxacin, with gastrointestinal-related adverse events occurring in 17.9% of patients who received lefamulin and 7.6% of patients who received moxifloxacin. Most reported events were either mild or moderate in severity. The most common treatment-emergent adverse events were diarrhea (12.2%), nausea (5.2%), and vomiting (3.3%) in the lefamulin group and nausea (1.9%), headache (1.6%), and urinary tract infection (1.6%) in the moxifloxacin group.Cost, tolerability are potential issuesCABP is one of the most common infectious causes of illness and hospitalization, especially in the elderly, and a common indication for antibiotic use. According to the Centers for Disease Control and Prevention, roughly 1 million people seek hospital care for CABP each year, and 50,000 people die from the disease. CABP is typically treated with macrolide and fluoroquinolone antibiotics.In an accompanying editorial, Preeti Malani, MD, of the department of internal medicine at the University of Michigan, writes that lefamulin is “an important addition to the current antibiotic armamentarium.” But she also notes that tolerability (especially diarrhea and vomiting) and cost will be issues for the drug. The IV formulation of lefamulin will have a wholesale price of $205 per day, and the oral treatment will cost $275 per day.”This is several-fold more than moxifloxacin or levofloxacin, which are the most commonly prescribed fluoroquinolones for CABP,” she writes.The FDA approved oral and intravenous (IV) lefamulin for the treatment of CABP in August based on the data from LEAP 2 and the previously published +LEAP 1 trial, in which 5 to 7 days of IV/oral lefamulin demonstrated non-inferiority to 7 days of IV/oral moxifloxacin with or without linezolid. The drug will be sold under the brand name Xenleta.See also:Sep 27 JAMA studySep 27 JAMA editorialAug 20 CIDRAP News story “FDA approves novel antibiotic for community-acquired pneumonia”
Steven Luatua crossed for Bristol’s only try of the afternoon, with Denny Solomona, Will Cliff and 17 points from the boot of Robert Du Preez sealing victory for the home side.Relive all of the action as we dissect the key moments, as they happened, from Saturday’s clash.
Both matches will be played at Melbourne Cricket Ground, which can hold more than 100,000 fans and hosts Australian football, cricket and rugby matches. CEST Upd. at 22:53 In Norway, the final stage of their trop, they will take on Valerenga on August 9. Real Madrid are on their way to Melbourne (Australia), the city where Rafa Benitez’s team will begin the second phase of their 2015-16 pre-season. They have travelled with 24 players, with Iker Casillas not among them having completed his move to Porto. Fabio Coentrao is also absent due to injury. Madrid’s flight is due to touch down in the Australian city at 11.30h on Monday, June 13 (19.30h local time), according to the club’s official website. 12/07/2015 Real Madrid will then continue onto China, Germany and Norway. In China they will play in a tournament (July 27 and 30) which also includes Inter Milan and AC Milan. EFE Back in Europe, they will play in the Audi Cup against Tottenham (August 4), with Bayern Munich or Milan then waiting in the final. It’s their first visit to Australia. While there they will play against Roma (July 18) and Manchester City (July 24).
With a larger yarding again last week, processors starting to hold stock, prices eased across all cattle with the Wednesday…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.
By Alana Mitchelson More than 300 Pakenham students have had their first day of school at the brand new John…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.
The opening round of the Celtic Challenge saw the all Galway meeting of Galway McDonagh and Galway Maroon in the sunshine in Pearse Stadium. Galway McDonagh emerged victorious and laid the platform for the win by building a 1-13 to 0-4 lead at the interval with the aid of the breeze.Conor Molloy, who finished with 0-10, shot 8 first half points with Mark Kennedy shooting the game’s first goal on 27 minutes to help build that sizeable lead. The McDonagh side were well worthy of that half time lead as they hurled with conviction in that opening period.The Galway Maroon side, to their credit, lifted their performance in the second half and a 33rd minute Niall Coen goal helped their cause. Still by the 49th minute the Galway McDonagh side still led by 1-19 to 1-7, before Conor Walsh struck for a goal. That score was quickly followed by Niall Coen’s second major and quick fire points from Adrian Gavin and Ross Albertini had the Maroon side back to 3-9 to 1-19 on 54 minutes.However, that was as close as it got and by the final whistle the Galway Maroon side were left to rue their 12 wides as Galway McDonagh emerged with the bragging rights on a final score line of 1-21 to 3-11.Galway McDonagh Squad: 1. Dara Conneely (Liam Mellows), 2. Sean Burke (Kilconieron), 3. Conor Lee (Clarinbridge), 4. Jack Hughes (Skehana), 5. Sean Joyce (Salthill Knocknacarra) 0-1, 6. Mark Gill (Castlegar), 7. Caimin Killeen (Loughrea), 8. Diarmuid O’Brien (Ballygar) 9. Dylan Shaughnessy (Loughrea), 10. TJ Brennan (Clarinbridge) 0-1, 11. Mark Kennedy (Clarinbridge) 1-3, 0-1 free, 12. Michael Glynn (Skehana), 13. Damien McGlynn (St Thomas) 0-1, 14. Conor Molly (Kilnadeema Leitrim) 0-10; 0-6 frees, 0-1 65, 15. Jack Egan (Kilnadeema Leitrim) 0-2, 16. Cillian Lawless (Athenry), 17. Neil Conneely (Portumna), 18. Isaac DeHora (Clarinbridge) 0-2, 19. Cathal Dolan (Kiltormer) 0-1, 20. Eoghan Kerin (Rahoon Newcastle).Management: Manager Damien Curley (Kiltormer), Willie Burke (Oranmore Maree), Gerry Spellman (Clarinbridge)Galway Maroon Squad: 1. Darrach Fahy (Ardrahan), 2. Sean Duffy (Killimor), 3. Ronan Flannery (Pearses), 4. Dean Callanan (Craughwell), 5. Adam Clarke (Craughwell), 6. Conor Walsh (Turloughmore) 1-4; 0-4 frees, 7. Noel Keogh (Athenry), 8. Enda Egan (Michael Cusacks) 0-1 free, 9. Paul Creaven (Killimordaly), 10. Ross Albertini (Ardrahan) 0-1, 11. John Fleming (Meelick Eyrecourt) 12. Nathan Earner (Meelick Eyrecourt), 13. Liam Quirke (Tynagh Abbey Duniry), 14. David Jordan (Tynagh Abbey Duniry) 0-1 free, 15. Niall Coen (Ballindereen) 2-2, 16. Diarmuid Mullen (Turloughmore) 0-1, 17. Evan Ryan (Tynagh Abbey Duniry), 18. Eoin Caulfield (Athenry), 19. Eoin O’Donnell (Ardrahan), 20. Jack Glynn (Turloughmore), 21. Matthew Lyons (Turloughmore), 22. Oisin Flaherty (Castlegar), 23. Adrian Gavin (Ballygar) 0-1.Management: Manager: Niall Canavan (Annaghdown), Selectors: Joe Hession (Turloughmore), Kevin Molloy (Kilnadeema Leitrim)Ref: Shane Hynes (Liam Mellows)The Panels Galway MaroonBack L-R: Kevin Molloy, Niall Canavan, Jack Glynn, Diarmuid Mullen, Niall Coen, David Jordan, Conor Walsh, Darrach Fahy, Enda Egan, Ronan Flannery, Noel Keogh, Oisin Flaherty, Eoin O’Donnell, Joe Hession.Front L-R: Matthew Lyons, Nathan Earner, Paul Creaven, Evan Ryan, Sean Duffy, Liam Quirke, Ross Albertini, Adam Clarke, Dean Callanan, Eoin Caulfield, John FlemingThanks to Tony Conneely https://www.flickr.com/photos/tonyconneely/albumsGalway McDonaghBack L-R: Willie Burke, TJ Brennan, Sean Burke, Conor Lee, Diarmuid O’Brien, Dylan Shaughnessy, Mark Gill, Jack Egan, Daragh Conneely, Sean Joyce, Jack Hughes, Eoghan Kerin, Damien CurleyFront L-R: Damien McGlynn, Conor Molloy, Micheal Glynn, Mark Kennedy, Isaac Dehora, Neil Connelly, Cillian Lawless, Caimin Killeen, Cathal DolanThanks to Tony Conneely https://www.flickr.com/photos/tonyconneely/albums Galway McDonagh 1-21 Galway Maroon 3-11 Celtic Challenge U17 Group A Meanwhile in the Connacht Centre of Excellence, Galway Tribesmen recorded an emphatic 5-23 to 0-9 win over Sligo…….Galway Tribesmen Squad: 1. Mark Connolly (Ahascragh Fohenagh) 2. Diarmuid McCartin (Craughwell) 3. Jack McCullogh (Athenry) 4. John Quinn (Salthill Knocknacarra) 5. Peter Martin (Kilconieron) 6. Jack Keville (Liam Mellows) 7. Jason Niland (St. Thomas) 8. Tom O’Connor (Moycullen) 9. Dara Coleman (Abbeyknockmoy) 10. Luke Lynskey (Killimordaly) 11. Jordan Ruffley (Rahoon Newcastle) (Capt) 12. Cillian Davoren (Moycullen) 13. Sean O’Brien (Portumna) 14. Fionn McDonagh (Moycullen) 15. James Smith (Castlegar) 16. Jake Hogan (Sylane) 17. Ronan Mitchell (Mullagh) 18. Conor Larkin (Meelick Eyrecourt) 19. Jack Tully (Ballindereen) 20. Stephen Doran (Padraig Pearses) 21. Hugh Moylan (Ballindereen) 22. Dylan Carroll (Castlegar) 23. Aaron Madden (Kilnadeema Leitrim) 24. Adrian Prendergast (Craughwell)Management: Manager: Gordon Crowley (Liam Mellows) Frank Enright(Moycullen), Denny Forde (Turloughmore). The Galway Tribesmen PanelBack L-R: Sean O’Brien, Dara Coleman, Jack McCullagh, Jack Keville, Peter Martin, James Smith, Fionn McDonagh, Mark Connolly, Stephen Doran, Adrian Prendergast, Jack Tully, John Quinn, Dylan CarrollFront L-R: Aaron Madden, Tom O’Connor, Luke Lynskey, Ronan Mitchell, Jason Niland, Diarmuid McCartin, Cillian Davoren, Conor Larkin, Hugh Moylan, Jordan Ruffleyprint WhatsApp Facebook Twitter Email
05.05.2019 (Sun) Connacht GAA Football Senior Championship – Quarter-FinalsLondain v Gaillimh (McGovern Park, Ruislip) 03.02.2019 (Sun) Allianz Hurling League – Round 2(All Games at 2pm unless otherwise stated)Roinn 1BCeatharlach v Gaillimh 24-25.08.2019 (Sat/Sun) Bord Gáis Energy GAA Hurling All-Ireland U20 Championship Final 22.06.2019 (Sat) GAA Football All-Ireland Senior Championship Round 2Féile Skills Star Challenge (National Games Development Centre, Abbotstown) 15-16.06.2019 (Sat/Sun) Leinster GAA Hurling Senior Championship – Round 5Áth Cliath v Gaillimh 12.05.2019 (Sun) Connacht GAA Football Senior Championship – Quarter-FinalRos Comáin v Leitrim v (Dr Hyde Park) GAA Diary 2019 01-02.06.2019 (Sat/Sun) GAA Football All-Ireland Senior Championship – Preliminary Round (If Required) 02.02.2019 (Sat) Allianz Football League – Round 2(All Games at 7pm unless otherwise stated)Roinn 1Áth Cliath v Gaillimh Allianz Hurling League – Round 4(All Games at 2pm unless otherwise stated)Roinn 1BUíbh Fhailí v Gaillimh (1pm) 17.02.2019 (Sun) Allianz Hurling League Round 3(All Games at 2pm unless otherwise stated)Roinn 1BGaillimh v Áth Cliath 15.06.2019 (Sat) Handball and Rounders Féile (Corcaigh) 16.03.2019 (Sat) Allianz Football League – Round 6 (All Games at 2pm unless otherwise stated)Roinn 1Gaillimh v Ros Comáin 24.02.2019 (Sun) Allianz Football League – Round 4(All Games at 2pm unless otherwise stated)Roinn 1Gaillimh v Ciarraí Electric Ireland GAA Football All-Ireland Minor Championship Semi-Final Allianz Hurling League Roinn 1 – Semi-FinalsWinner Quarter-Final A v Winner Quarter-Final DWinner Quarter-Final B v Winner Quarter-Final C Important Dates19-20.01.2019 (Sat/Sun) AIB GAA Football All-Ireland Intermediate Club Championship Semi-FinalsConnacht v UlsterAIB GAA Football All-Ireland Junior Club Championship Semi-FinalsConnacht v UlsterAIB GAA Hurling All-Ireland Intermediate Club Championship Semi-FinalsConnacht v UlsterAIB GAA Hurling All-Ireland Junior Club Championship Semi-FinalsConnacht v Ulster Electric Ireland GAA Hurling All-Ireland Minor Championship Quarter-Final Round 2Winner of Round 1 v Gaillimh 10.02.2019 (Sun) AIB GAA Hurling All-Ireland Intermediate & Junior Club Finals (Páirc an Chrócaigh)Allianz Football League – Round 3(All Games at 2pm unless otherwise stated)Roinn 1Muineachán v Gaillimh 27.01.2019 (Sun) Allianz Football League – Round 1(All Games at 2pm unless otherwise stated)Roinn 1Gaillimh v An Cabhán (2.30pm) 26.05.2019 (Sun) Connacht GAA Football Senior Championship – Semi-FinalNua Eabhrac / Maigh Eo v Leitrim / Ros Comáin 24.03.2019 (Sun) Allianz Football League – Round 7(All Games at 2pm unless otherwise stated)Roinn 1Tír Eoghain v GaillimhAllianz Hurling League Roinn 1 – Final 16.02.2019 (Sat) AIB GAA Football All-Ireland Senior Club Championship Semi-FinalsConnacht v UlsterElectric Ireland Higher Education GAA Sigerson Cup Semi-Finals (Munster C.A. – Mallow Sports Complex, Corcaigh) 31.03.2019 (Sun) Allianz Football League Roinn 1 & 2 Final (Páirc an Chrócaigh) 17.03.2019 (Sun) AIB GAA All-Ireland Senior Club Football & Hurling Finals (Páirc an Chrócaigh) 03-05.08.2019 (Sat/Sun/Mon) GAA Football All-Ireland Senior Championship Quarter-Final Group Stage Phase 3Group 1Connacht Runner-Up/Round 3 Winner v Ulster Provincial WinnerGroup 2Munster Runner-Up/Round 3 Winner v Connacht Provincial Winner 06-07.07.2019 (Sat/Sun)GAA Football All-Ireland Senior Championship Round 4GAA Football All-Ireland Junior Championship Semi-FinalsConnacht v LeinsterBritain v Munster Bord Gáis GAA Hurling All-Ireland U20 Championship – Semi-FinalsLeinster Winner v Munster Runner-UpMunster Winner v Leinster Runner-Up 30.06.2019 (Sun) Munster GAA Hurling Senior Championship FinalLeinster GAA Hurling Senior Championship Final (Páirc an Chrócaigh) 25-26.05.2019 (Sat/Sun) Leinster GAA Hurling Senior Championship – Round 3AGaillimh v Loch Garman 13-14.07.2019 (Sat/Sun) GAA Football All-Ireland Senior Championship Quarter-Final Group Stage Phase 1Group 1Munster Provincial Winner v Connacht Runner-Up/Round 3 WinnerGroup 2Connacht Provincial Winner v Ulster Runner-Up/Round 3 Winner GAA Hurling All-Ireland Senior Championship Quarter-FinalsLeinster Runner-Up v Runner-Up Joe McDonagh Cup/3rd Placed Team Munster GroupMunster Runner-Up v Group v Winner Tier Joe McDonagh Cup/3rd Placed Team Leinster Group 01.09.2019 (Sun) GAA Football All-Ireland Senior Championship Final (Replay 14.09.2019 – Sat)Electric Ireland GAA Football All-Ireland Minor Championship Final 20-21.07.2019 (Sat/Sun) GAA Football All-Ireland Senior Championship Quarter-Final Group Stage Phase 2Group 1Munster Provincial Winner v Ulster Provincial WinnerConnacht Runner-Up/Round 3 Winner v Leinster Runner-Up/Round 3 WinnerGroup 2Leinster Provincial Winner v Connacht Provincial WinnerMunster Runner-Up/Round 3 Winner v Ulster Runner-Up/Round 3 Winner 08-09.06.2019 (Sat/Sun) Leinster GAA Hurling Senior Championship – Round 4Loch Garman v CeatharlachCill Chainnigh v Gaillimh 11.08.2019 (Sun) GAA Football All-Ireland Senior Championship Semi-Final (Replay 17.08.2019)Quarter-Final Group Winner v Quarter-Final Group Runner Up 03.08.2019 (Sat) Donnelly All-Ireland Poc Fada Finals (Annaverna Mountain, Ravensdale, Co Louth) 20.02.2019 (Wed) Electric Ireland Higher Education GAA Sigerson Cup Final 16.06.2019 (Sun) Connacht GAA Football Senior Championship Final 27.07.2019 (Sat) GAA Hurling All-Ireland Senior Championship Semi-Final (Replay 03-05.08.2019)Provincial Winner v Quarter-Final Winner Electric Ireland GAA Football All-Ireland Minor Championship Quarter-FinalsConnacht Winner v Leinster Runners UpLeinster Winner v Connacht Runners Up 07-09.06.2019 (Fri/Sat/Sun) Féile na nGael (Corcaigh) Electric Ireland GAA Hurling All-Ireland Minor Championship Semi-Final 10.08.2019 (Sat) GAA Football All-Ireland Senior Championship Semi-Final (Replay 17.08.2019)Quarter-Final Group Winner v Quarter-Final Group Runner Up 18.08.2019 (Sun) GAA Hurling All-Ireland Senior Championship Final (Replay 07.09.2019 – Sat)Electric Ireland GAA Hurling All-Ireland Minor Championship Final GAA Hurling All-Ireland Senior Championship Preliminary Quarter-FinalsWinner Joe McDonagh Cup v 3rd Placed Team Leinster GroupRunner-Up Joe McDonagh Cup v 3rd Placed Team Munster Group 06.04.2019 (Sat) Masita GAA All Ireland Football Post Primary Schools Finals (Páirc an Chrócaigh) Electric Ireland GAA Hurling All-Ireland Minor Championship Semi-Final 08.09.2019 (Sun) Liberty Insurance All-Ireland Camogie Championship Finals 29-30.06.2019 (Fri/Sat/Sun) Féile na nÓg (Connacht) The GAA have revealed its Master Fixture plan for 2019 with the national calendar beginning on the weekend of the 19th and 20th of January with the All-Ireland Intermediate and Junior Club Hurling and Football Semi-Finals. The Allianz National league for Galway’s Footballers and Hurlers will begin on Sunday the 27th with a home double header against Laois in the Hurling at 12.30 followed by the Footballers game with Cavan at 2.30. 29.06.2019 (Sat) GAA Football All-Ireland Senior Championship Round 3 Eirgrid GAA Football All-Ireland U20 Championship Final 27-28.07.2019 (Sat/Sun) Eirgrid GAA Football All-Ireland U20 Championship Semi-FinalsConnacht v Leinster GAA Football All-Ireland Junior Championship Final 19.05.2019 (Sun) Connacht GAA Football Senior Championship – Semi-FinalSligeach v Londain / Gaillimh (Markievicz Park) 11-12.05.2019 (Sat/Sun) Leinster GAA Hurling Senior Championship – Round 1Gaillimh v Ceatharlach 23.06.2019 (Sun) Ulster GAA Football Senior Championship FinalLeinster GAA Football Senior Championship Final (Páirc an Chrócaigh) Electric Ireland GAA Hurling All-Ireland Minor Championship Quarter-Final Round 1Leinster Runner-Up v Munster Runner-Up Electric Ireland GAA Football All-Ireland Minor Championship Semi-Final 23.02.2019 (Sat) Electric Ireland Higher Education GAA Fitzgibbon Cup Final (Waterford I.T.) 09.02.2019 (Sat) AIB GAA Hurling All-Ireland Senior Club Championship Semi-FinalsConnacht v UlsterAIB GAA Football All-Ireland Intermediate & Junior Club Finals (Páirc an Chrócaigh) 03.03.2019 (Sun) Allianz Hurling League – Round 5(All Games at 2.00pm unless otherwise stated)Roinn 1BPort Láirge v Gaillimh Allianz Hurling League – Round 1(All Games at 2pm unless otherwise stated)Roinn 1BGaillimh v Laois (12.30pm) 01-03.06.2019 (Sat/Sun/Mon) Comórtas Peile na Gaeltachta, Gallaras 10.03.2019 (Sun) Allianz Hurling League – Quarter-FinalsRoinn 1(A) Top Team 1A v 4th Team 1B(B) 2nd Team 1A v 3rd Team 1B(C) 3rd Team 1A v 2nd Team 1B(D) 4th Team 1A v Top Team 1B 28.07.2019 (Sun) GAA Hurling All-Ireland Senior Championship Semi-Final (Replay 03-05.08.2019)Provincial Winner v Quarter-Final Winner GAA Hurling All-Ireland Senior Championship Relegation Play-off (If Required) Electric Ireland GAA Hurling All-Ireland Minor Championship Quarter-Final Round 3Loser of Round 1 v Gaillimh 08.06.2019 (Sat)GAA Football All-Ireland Senior Championship – Round 1 30.03.2019 (Sat) Masita GAA All Ireland Hurling Post Primary Schools Finals (Semple Stadium, Thurles) 02.03.2019 (Sat) Allianz Football League – Round 5(All Games at 7pm unless otherwise stated)Roinn 1Maigh Eo v Gaillimh (7.15pm) 15.09.2019 (Sun) TG4 All-Ireland Ladies Football Finalsprint WhatsApp Facebook Twitter Email
Gerry Murphy, George McDonagh and Kevin Dwyer were joined by Brendan Hennessy, Gordon Duane, Eric Elwood, William Davies, Alan Giblin, Siobhan Lally, Ross Forde, Craig Breen and Garry Jennings as they look back at the weekend’s sport and look ahead to the Corrib Oil Galway International Rally that takes place next weekend. print WhatsApp Facebook Twitter Email
The longest continuous section of the Mountains-to-Sea Trail is now complete in Western North Carolina thanks to Carolina Mountain Club volunteers and N.C. State Parks staff. “I feel like it was extremely successful, efficient and educational for both CMC and N.C. State Parks staff,” Crocker wrote. “This was a perfect example of multiple agencies and volunteers coming together to accomplish something through teamwork and collaboration,” N.C. Trails Program Manager Scott Crocker wrote in a letter to CMC volunteers. “A special thanks to Tom Weaver and Les Love and others with the CMC that helped organize the trail work days.”The new trail bypasses the Rattlesnake and Sherrill Cove tunnels on the Blue Ridge Parkway near the Great Smoky Mountains National Park, meaning that the MST is now complete from Clingmans Dome on the North Carolina-Tennessee border to Stone Mountain State Park, which straddles Alleghany and Wilkes counties near Elkin.For the first time, N.C. State Parks used a hybrid approach to build the trail, using a machine to rough in the route and volunteers with hand tools to conduct the finishing work. Work is now underway to blaze the final route through the mountains, allowing it to be open to the public in the near future.For more information about the MST, including an interactive map and downloadable section guides, visit www.mountainstoseatrail.org.
CALGARY – Central Canadian consumers can expect to pay less for natural gas to heat their homes as a new pipeline connects shale gas from the northeastern United States to the Dawn storage hub near Sarnia in southwestern Ontario.The Rover Pipeline last week won approval from the U.S. energy regulator to begin shipping at its capacity of 3.25 billion cubic feet per day of natural gas, transporting the fuel from Marcellus and Utica shale wells in the northeastern U.S. to American markets and, via the Vector Pipeline connection, to the Dawn hub for distribution into the Canadian market.Chris Shorts, director of storage, transportation, marketing and utilization for Union Gas Ltd., operator of the Dawn hub, says the new source of gas will tend to push natural gas prices lower, although he couldn’t estimate what that will do to an average consumers’ bill.He says Union Gas last year increased its capacity to accept gas on the Vector connection by about 300 million cf/d to about 1.8 billion cf/d, although the actual amount delivered each day will vary according to sales contracts between shippers in the U.S. and buyers in Canada.Natural gas volumes arriving at Dawn are already being affected by about 1.4 billion cf/d in western Canadian natural gas added late last year after TransCanada Corp. brought in discount tolls to increase the use of its Canadian Mainline gas system.Consumer natural gas rates in Ontario and Quebec are affected by market gas prices but also take into account transmission and management costs.“It will have a downward pressure,” said Shorts.“Prices are as low as they’ve been in the last 10 years and there’s more downward pressure, because of the incremental supply, than there would be upward pressure.”Companies in this article: (TSX:TRP)